Head to head
Buffalo Bills v Carolina Panthers — every meeting since 2001
Buffalo Bills and Carolina Panthers have met 7 times since 2001. BUF lead the regular-season series 5-2. Against the closing spread BUF are 4-3. The highest-scoring meeting produced 49 points in 2025; the widest margin was 31.
BUF record
5-2
regular season, 2001–2025
BUF v the spread
4-3
covered–against
Highest scoring
49
combined, 2025
Widest margin
31
2025 season
Every meeting
7 games, 2001–2025| Game | Result | Total | Line | Won by |
|---|---|---|---|---|
| 2025 WK 8 | BUF 40atCAR 9 | 47.5 | CAR -7 | BUF by 31 |
| 2021 WK 15 | CAR 14atBUF 31 | 43 | BUF +14 | BUF by 17 |
| 2017 WK 2 | BUF 3atCAR 9 | 43 | CAR +6.5 | CAR by 6 |
| 2013 WK 2 | CAR 23atBUF 24 | 43.5 | BUF -3.5 | BUF by 1 |
| 2009 WK 7 | BUF 20atCAR 9 | 37 | CAR +7 | BUF by 11 |
| 2005 WK 12 | CAR 13atBUF 9 | 36.5 | BUF -4 | CAR by 4 |
| 2001 WK 13 | CAR 24atBUF 25 | 36.5 | BUF +3.5 | BUF by 1 |
BUF in the last meetings
- Last 32-1
- Last 54-1
The extremes
- Highest scoring2025 week 8 · BUF 40 at CAR 949 points
- Lowest scoring2017 week 2 · BUF 3 at CAR 912 points
- Widest margin2025 week 8 · BUF 40 at CAR 931 points
By starting quarterback
regular season, 2001–2025No meeting on file names both starting quarterbacks.
7 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
By head coach
regular season, 2001–2025No meeting on file names both head coaches.
7 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
Players, since 2021
a shorter window than aboveEverything above this line covers 2001 onwards, because that is how far the schedule and the closing lines go back. Per-player box scores start at 2021, so any figure naming a player covers the 5 seasons from 2021 and no more. The two windows are kept apart rather than blended, and neither is presented as the complete history: these clubs have played each other for far longer than this database reaches, and nothing on this page covers the seasons before 2001.
Most touchdowns
since 2021 · 2 meetings
- Josh Allen QB · BUF · 2g6 TD
- Cam Newton QB · CAR · 1g2 TD
- Gabe Davis WR · BUF · 1g2 TD
- James Cook RB · BUF · 1g2 TD
- Stefon Diggs WR · BUF · 1g1 TD
- Ameer Abdullah RB · CAR · 1g1 TD
Most passing yards
since 2021 · 2 meetings
- Josh Allen QB · BUF · 2g373 yds
- Andy Dalton QB · CAR · 1g175 yds
- Cam Newton QB · CAR · 1g156 yds
- Mitchell Trubisky QB · BUF · 1g22 yds
Most rushing yards
since 2021 · 2 meetings
- James Cook RB · BUF · 1g216 yds
- Devin Singletary RB · BUF · 1g86 yds
- Chuba Hubbard RB · CAR · 2g74 yds
- Cam Newton QB · CAR · 1g71 yds
- Rico Dowdle RB · CAR · 1g54 yds
- Robbie Chosen WR · CAR · 1g33 yds
Most receiving yards
since 2021 · 2 meetings
- Tetairoa McMillan WR · CAR · 1g99 yds
- Khalil Shakir WR · BUF · 1g88 yds
- Gabe Davis WR · BUF · 1g85 yds
- Dawson Knox TE · BUF · 2g53 yds
- Ameer Abdullah RB · CAR · 1g48 yds
- DJ Moore WR · CAR · 1g48 yds
