Head to head
Buffalo Bills v Indianapolis Colts — every meeting since 1999
Buffalo Bills and Indianapolis Colts have met 16 times since 1999. BUF trail the regular-season series 5-10, and the two have met 1 time in the postseason (BUF 1-0). Against the closing spread BUF are 5-10. The highest-scoring meeting produced 68 points in 2001; the widest margin was 32.
BUF record
5-10
regular season, 1999–2024
BUF v the spread
5-10
covered–against
Highest scoring
68
combined, 2001
Widest margin
32
2018 season
Every meeting
16 games, 1999–2024| Game | Result | Total | Line | Won by |
|---|---|---|---|---|
| 2024 WK 10 | BUF 30atIND 20 | 46.5 | IND -4.5 | BUF by 10 |
| 2021 WK 11 | IND 41atBUF 15 | 49.5 | BUF +7.5 | IND by 26 |
| 2020 WC | IND 24atBUF 27 | 50.5 | BUF +7 | BUF by 3 |
| 2018 WK 7 | BUF 5atIND 37 | 43.5 | IND +7 | IND by 32 |
| 2017 WK 14 | IND 7atBUF 13 | 36.5 | BUF +3.5 | BUF by 6 |
| 2015 WK 1 | IND 14atBUF 27 | 44.5 | BUF -1 | BUF by 13 |
| 2012 WK 12 | BUF 13atIND 20 | 51 | IND +2 | IND by 7 |
| 2009 WK 17 | IND 7atBUF 30 | 32.5 | BUF +9 | BUF by 23 |
| 2006 WK 10 | BUF 16atIND 17 | 44.5 | IND +12 | IND by 1 |
| 2003 WK 12 | IND 17atBUF 14 | 38.5 | BUF -3 | IND by 3 |
| 2001 WK 8 | IND 30atBUF 14 | 44.5 | BUF -3 | IND by 16 |
| 2001 WK 2 | BUF 26atIND 42 | 44.5 | IND +10 | IND by 16 |
| 2000 WK 15 | BUF 20atIND 44 | 45 | IND +6 | IND by 24 |
| 2000 WK 5 | IND 18atBUF 16 | 44 | BUF +1.5 | IND by 2 |
| 1999 WK 17 | IND 6atBUF 31 | 42 | BUF -1.5 | BUF by 25 |
| 1999 WK 1 | BUF 14atIND 31 | 45.5 | IND -3 | IND by 17 |
BUF in the last meetings
- Last 31-2
- Last 53-2
- Last 104-6
The extremes
- Highest scoring2001 week 2 · BUF 26 at IND 4268 points
- Lowest scoring2017 week 14 · IND 7 at BUF 1320 points
- Widest margin2018 week 7 · BUF 5 at IND 3732 points
By starting quarterback
regular season, 1999–2024| BUF | IND | Met | BUF record |
|---|---|---|---|
| Rob Johnson | Peyton Manning | 5 | 1-4 |
10 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
By head coach
regular season, 1999–2024| BUF | IND | Met | BUF record |
|---|---|---|---|
| Wade Phillips | Jim Mora | 4 | 1-3 |
| Sean McDermott | Frank Reich | 2 | 0-2 |
| Gregg Williams | Jim Mora | 2 | 0-2 |
7 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
Players, since 2021
a shorter window than aboveEverything above this line covers 1999 onwards, because that is how far the schedule and the closing lines go back. Per-player box scores start at 2021, so any figure naming a player covers the 4 seasons from 2021 and no more. The two windows are kept apart rather than blended, and neither is presented as the complete history: these clubs have played each other for far longer than this database reaches, and nothing on this page covers the seasons before 1999.
Most touchdowns
since 2021 · 2 meetings
- Jonathan Taylor RB · IND · 1g5 TD
- Josh Allen QB · BUF · 2g3 TD
- Joe Flacco QB · IND · 1g2 TD
- Stefon Diggs WR · BUF · 1g2 TD
- Carson Wentz QB · IND · 1g1 TD
- Tyler Goodson RB · IND · 1g1 TD
Most passing yards
since 2021 · 2 meetings
- Josh Allen QB · BUF · 2g489 yds
- Joe Flacco QB · IND · 1g272 yds
- Carson Wentz QB · IND · 1g106 yds
- Mitchell Trubisky QB · BUF · 1g19 yds
Most rushing yards
since 2021 · 2 meetings
- Jonathan Taylor RB · IND · 2g299 yds
- James Cook RB · BUF · 1g80 yds
- Josh Allen QB · BUF · 2g68 yds
- Matt Breida RB · BUF · 1g51 yds
- Nyheim Hines RB · IND · 1g31 yds
- Carson Wentz QB · IND · 1g18 yds
Most receiving yards
since 2021 · 2 meetings
- Dawson Knox TE · BUF · 2g120 yds
- Mack Hollins WR · BUF · 1g86 yds
- Alec Pierce WR · IND · 1g81 yds
- Josh Downs WR · IND · 1g72 yds
- Adonai Mitchell WR · IND · 1g71 yds
- Khalil Shakir WR · BUF · 1g58 yds
