Head to head
Buffalo Bills v San Francisco 49ers — every meeting since 2001
Buffalo Bills and San Francisco 49ers have met 7 times since 2001. BUF lead the regular-season series 4-3. Against the closing spread BUF are 4-3. The highest-scoring meeting produced 61 points in 2016; the widest margin was 42.
BUF record
4-3
regular season, 2001–2024
BUF v the spread
4-3
covered–against
Highest scoring
61
combined, 2016
Widest margin
42
2012 season
Every meeting
7 games, 2001–2024| Game | Result | Total | Line | Won by |
|---|---|---|---|---|
| 2024 WK 13 | SF 10atBUF 35 | 45 | BUF +6.5 | BUF by 25 |
| 2020 WK 13 | BUF 34atSF 24 | 48 | SF +1.5 | BUF by 10 |
| 2016 WK 6 | SF 16atBUF 45 | 44 | BUF +7.5 | BUF by 29 |
| 2012 WK 5 | BUF 3atSF 45 | 45.5 | SF +10 | SF by 42 |
| 2008 WK 13 | SF 10atBUF 3 | 43 | BUF +6.5 | SF by 7 |
| 2004 WK 16 | BUF 41atSF 7 | 41.5 | SF -10 | BUF by 34 |
| 2001 WK 12 | BUF 0atSF 35 | 44.5 | SF +8.5 | SF by 35 |
BUF in the last meetings
- Last 33-0
- Last 53-2
The extremes
- Highest scoring2016 week 6 · SF 16 at BUF 4561 points
- Lowest scoring2008 week 13 · SF 10 at BUF 313 points
- Widest margin2012 week 5 · BUF 3 at SF 4542 points
By starting quarterback
regular season, 2001–2024No meeting on file names both starting quarterbacks.
7 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
By head coach
regular season, 2001–2024| BUF | SF | Met | BUF record |
|---|---|---|---|
| Sean McDermott | Kyle Shanahan | 2 | 2-0 |
5 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
Players, since 2021
a shorter window than aboveEverything above this line covers 2001 onwards, because that is how far the schedule and the closing lines go back. Per-player box scores start at 2021, so any figure naming a player covers the 4 seasons from 2021 and no more. The two windows are kept apart rather than blended, and neither is presented as the complete history: these clubs have played each other for far longer than this database reaches, and nothing on this page covers the seasons before 2001.
Most touchdowns
since 2021 · 1 meeting
- Josh Allen QB · BUF · 1g4 TD
- Mack Hollins WR · BUF · 1g1 TD
- James Cook RB · BUF · 1g1 TD
- Isaac Guerendo RB · SF · 1g1 TD
- Ray Davis RB · BUF · 1g1 TD
Most passing yards
since 2021 · 1 meeting
- Josh Allen QB · BUF · 1g148 yds
- Brock Purdy QB · SF · 1g94 yds
- Mitchell Trubisky QB · BUF · 1g4 yds
Most rushing yards
since 2021 · 1 meeting
- James Cook RB · BUF · 1g107 yds
- Jordan Mason RB · SF · 1g78 yds
- Ray Davis RB · BUF · 1g63 yds
- Christian McCaffrey RB · SF · 1g53 yds
- Ty Johnson RB · BUF · 1g28 yds
- Isaac Guerendo RB · SF · 1g19 yds
Most receiving yards
since 2021 · 1 meeting
- Dawson Knox TE · BUF · 1g56 yds
- Jauan Jennings WR · SF · 1g56 yds
- Khalil Shakir WR · BUF · 1g30 yds
- Deebo Samuel Sr. WR · SF · 1g20 yds
- Christian McCaffrey RB · SF · 1g14 yds
- Quintin Morris TE · BUF · 1g14 yds
