Head to head
Indianapolis Colts v San Francisco 49ers — every meeting since 2001
Indianapolis Colts and San Francisco 49ers have met 7 times since 2001. IND lead the regular-season series 5-2. Against the closing spread IND are 5-2. The highest-scoring meeting produced 75 points in 2025; the widest margin was 25.
IND record
5-2
regular season, 2001–2025
IND v the spread
5-2
covered–against
Highest scoring
75
combined, 2025
Widest margin
25
2005 season
Every meeting
7 games, 2001–2025| Game | Result | Total | Line | Won by |
|---|---|---|---|---|
| 2025 WK 16 | SF 48atIND 27 | 46.5 | IND -4.5 | SF by 21 |
| 2021 WK 7 | IND 30atSF 18 | 41.5 | SF +3.5 | IND by 12 |
| 2017 WK 5 | SF 23atIND 26 | 43.5 | IND -1 | IND by 3 |
| 2013 WK 3 | IND 27atSF 7 | 45.5 | SF +10.5 | IND by 20 |
| 2009 WK 8 | SF 14atIND 18 | 45 | IND +13 | IND by 4 |
| 2005 WK 5 | IND 28atSF 3 | 47 | SF -14 | IND by 25 |
| 2001 WK 11 | SF 40atIND 21 | 52.5 | IND +2.5 | SF by 19 |
IND in the last meetings
- Last 32-1
- Last 54-1
The extremes
- Highest scoring2025 week 16 · SF 48 at IND 2775 points
- Lowest scoring2005 week 5 · IND 28 at SF 331 points
- Widest margin2005 week 5 · IND 28 at SF 325 points
By starting quarterback
regular season, 2001–2025| IND | SF | Met | IND record |
|---|---|---|---|
| Peyton Manning | Alex Smith | 2 | 2-0 |
5 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
By head coach
regular season, 2001–2025No meeting on file names both head coaches.
7 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
Players, since 2021
a shorter window than aboveEverything above this line covers 2001 onwards, because that is how far the schedule and the closing lines go back. Per-player box scores start at 2021, so any figure naming a player covers the 5 seasons from 2021 and no more. The two windows are kept apart rather than blended, and neither is presented as the complete history: these clubs have played each other for far longer than this database reaches, and nothing on this page covers the seasons before 2001.
Most touchdowns
since 2021 · 2 meetings
- Brock Purdy QB · SF · 1g5 TD
- Carson Wentz QB · IND · 1g3 TD
- Philip Rivers QB · IND · 1g2 TD
- Christian McCaffrey RB · SF · 1g2 TD
- Jonathan Taylor RB · IND · 2g2 TD
- Alec Pierce WR · IND · 1g2 TD
Most passing yards
since 2021 · 2 meetings
- Brock Purdy QB · SF · 1g295 yds
- Philip Rivers QB · IND · 1g277 yds
- Jimmy Garoppolo QB · SF · 1g181 yds
- Carson Wentz QB · IND · 1g150 yds
Most rushing yards
since 2021 · 2 meetings
- Jonathan Taylor RB · IND · 2g153 yds
- Christian McCaffrey RB · SF · 1g117 yds
- Elijah Mitchell RB · SF · 1g107 yds
- Carson Wentz QB · IND · 1g23 yds
- Brian Robinson RB · SF · 1g20 yds
- Nyheim Hines RB · IND · 1g14 yds
Most receiving yards
since 2021 · 2 meetings
- Michael Pittman WR · IND · 2g137 yds
- George Kittle TE · SF · 1g115 yds
- Deebo Samuel Sr. WR · SF · 1g100 yds
- Alec Pierce WR · IND · 1g86 yds
- Jauan Jennings WR · SF · 1g71 yds
- Josh Downs WR · IND · 1g65 yds
