Head to head
Jacksonville Jaguars v San Francisco 49ers — every meeting since 1999
Jacksonville Jaguars and San Francisco 49ers have met 8 times since 1999. JAX trail the regular-season series 3-5. Against the closing spread JAX are 3-5. The highest-scoring meeting produced 77 points in 2017; the widest margin was 38.
JAX record
3-5
regular season, 1999–2025
JAX v the spread
3-5
covered–against
Highest scoring
77
combined, 2017
Widest margin
38
1999 season
Every meeting
8 games, 1999–2025| Game | Result | Total | Line | Won by |
|---|---|---|---|---|
| 2025 WK 4 | JAX 26atSF 21 | 45.5 | SF +3.5 | JAX by 5 |
| 2023 WK 10 | SF 34atJAX 3 | 44.5 | JAX -3 | SF by 31 |
| 2021 WK 11 | SF 30atJAX 10 | 45 | JAX -6.5 | SF by 20 |
| 2017 WK 16 | JAX 33atSF 44 | 43 | SF -4 | SF by 11 |
| 2013 WK 8 | SF 42atJAX 10 | 40 | JAX -16 | SF by 32 |
| 2009 WK 12 | JAX 3atSF 20 | 42.5 | SF +3 | SF by 17 |
| 2005 WK 15 | SF 9atJAX 10 | 39.5 | JAX +14.5 | JAX by 1 |
| 1999 WK 1 | SF 3atJAX 41 | 49 | JAX +5.5 | JAX by 38 |
JAX in the last meetings
- Last 31-2
- Last 51-4
The extremes
- Highest scoring2017 week 16 · JAX 33 at SF 4477 points
- Lowest scoring2005 week 15 · SF 9 at JAX 1019 points
- Widest margin1999 week 1 · SF 3 at JAX 4138 points
By starting quarterback
regular season, 1999–2025| JAX | SF | Met | JAX record |
|---|---|---|---|
| Trevor Lawrence | Brock Purdy | 2 | 1-1 |
| David Garrard | Alex Smith | 2 | 1-1 |
4 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
By head coach
regular season, 1999–2025No meeting on file names both head coaches.
8 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
Players, since 2021
a shorter window than aboveEverything above this line covers 1999 onwards, because that is how far the schedule and the closing lines go back. Per-player box scores start at 2021, so any figure naming a player covers the 5 seasons from 2021 and no more. The two windows are kept apart rather than blended, and neither is presented as the complete history: these clubs have played each other for far longer than this database reaches, and nothing on this page covers the seasons before 1999.
Most touchdowns
since 2021 · 3 meetings
- Brock Purdy QB · SF · 2g5 TD
- Jimmy Garoppolo QB · SF · 1g2 TD
- George Kittle TE · SF · 2g2 TD
- Deebo Samuel Sr. WR · SF · 2g2 TD
- Brandon Aiyuk WR · SF · 2g2 TD
- Kyle Juszczyk FB · SF · 1g1 TD
Most passing yards
since 2021 · 3 meetings
- Brock Purdy QB · SF · 2g605 yds
- Trevor Lawrence QB · JAX · 3g517 yds
- Jimmy Garoppolo QB · SF · 1g176 yds
- Sam Darnold QB · SF · 1g6 yds
- C.J. Beathard QB · JAX · 1g5 yds
Most rushing yards
since 2021 · 3 meetings
- Travis Etienne RB · JAX · 2g159 yds
- Christian McCaffrey RB · SF · 2g144 yds
- Deebo Samuel Sr. WR · SF · 2g108 yds
- Jeff Wilson RB · SF · 1g50 yds
- Trevor Lawrence QB · JAX · 3g37 yds
- Trey Sermon RB · SF · 1g32 yds
Most receiving yards
since 2021 · 3 meetings
- George Kittle TE · SF · 2g150 yds
- Brandon Aiyuk WR · SF · 2g140 yds
- Christian McCaffrey RB · SF · 2g139 yds
- Christian Kirk WR · JAX · 1g104 yds
- Kyle Juszczyk FB · SF · 3g65 yds
- Jake Tonges TE · SF · 1g58 yds
