Head to head
San Francisco 49ers v Tennessee Titans — every meeting since 1999
San Francisco 49ers and Tennessee Titans have met 7 times since 1999. SF lead the regular-season series 4-3. Against the closing spread SF are 5-2. The highest-scoring meeting produced 61 points in 2025; the widest margin was 14.
SF record
4-3
regular season, 1999–2025
SF v the spread
5-2
covered–against
Highest scoring
61
combined, 2025
Widest margin
14
2013 season
Every meeting
7 games, 1999–2025| Game | Result | Total | Line | Won by |
|---|---|---|---|---|
| 2025 WK 15 | TEN 24atSF 37 | 44.5 | SF +12.5 | SF by 13 |
| 2021 WK 16 | SF 17atTEN 20 | 45.5 | TEN -3.5 | TEN by 3 |
| 2017 WK 15 | TEN 23atSF 25 | 44.5 | SF +2.5 | SF by 2 |
| 2013 WK 7 | SF 31atTEN 17 | 41 | TEN -3 | SF by 14 |
| 2009 WK 9 | TEN 34atSF 27 | 41 | SF +4.5 | TEN by 7 |
| 2005 WK 12 | SF 22atTEN 33 | 42.5 | TEN +7 | TEN by 11 |
| 1999 WK 4 | TEN 22atSF 24 | 40.5 | SF +1.5 | SF by 2 |
SF in the last meetings
- Last 32-1
- Last 53-2
The extremes
- Highest scoring2025 week 15 · TEN 24 at SF 3761 points
- Lowest scoring2021 week 16 · SF 17 at TEN 2037 points
- Widest margin2013 week 7 · SF 31 at TEN 1714 points
By starting quarterback
regular season, 1999–2025No meeting on file names both starting quarterbacks.
7 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
By head coach
regular season, 1999–2025No meeting on file names both head coaches.
7 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
Players, since 2021
a shorter window than aboveEverything above this line covers 1999 onwards, because that is how far the schedule and the closing lines go back. Per-player box scores start at 2021, so any figure naming a player covers the 5 seasons from 2021 and no more. The two windows are kept apart rather than blended, and neither is presented as the complete history: these clubs have played each other for far longer than this database reaches, and nothing on this page covers the seasons before 1999.
Most touchdowns
since 2021 · 2 meetings
- Brock Purdy QB · SF · 1g3 TD
- Jauan Jennings WR · SF · 1g2 TD
- Cam Ward QB · TEN · 1g2 TD
- Ryan Tannehill QB · TEN · 1g1 TD
- Jimmy Garoppolo QB · SF · 1g1 TD
- Christian McCaffrey RB · SF · 1g1 TD
Most passing yards
since 2021 · 2 meetings
- Jimmy Garoppolo QB · SF · 1g322 yds
- Brock Purdy QB · SF · 1g295 yds
- Ryan Tannehill QB · TEN · 1g209 yds
- Cam Ward QB · TEN · 1g170 yds
Most rushing yards
since 2021 · 2 meetings
- Tony Pollard RB · TEN · 1g104 yds
- Christian McCaffrey RB · SF · 1g73 yds
- Jeff Wilson RB · SF · 1g45 yds
- Brock Purdy QB · SF · 1g44 yds
- Tyjae Spears RB · TEN · 1g34 yds
- Deebo Samuel Sr. WR · SF · 1g32 yds
Most receiving yards
since 2021 · 2 meetings
- Deebo Samuel Sr. WR · SF · 1g159 yds
- A.J. Brown WR · TEN · 1g145 yds
- George Kittle TE · SF · 2g109 yds
- Ricky Pearsall WR · SF · 1g96 yds
- Jauan Jennings WR · SF · 2g56 yds
- Kyle Juszczyk FB · SF · 2g52 yds
