Head to head
Carolina Panthers v San Francisco 49ers — every meeting since 1999
Carolina Panthers and San Francisco 49ers have met 16 times since 1999. CAR lead the regular-season series 10-5, and the two have met 1 time in the postseason (CAR 0-1). Against the closing spread CAR are 8-7. The highest-scoring meeting produced 73 points in 2016; the widest margin was 38.
CAR record
10-5
regular season, 1999–2025
CAR v the spread
8-7
covered–against
Highest scoring
73
combined, 2016
Widest margin
38
2019 season
Every meeting
16 games, 1999–2025| Game | Result | Total | Line | Won by |
|---|---|---|---|---|
| 2025 WK 12 | CAR 9atSF 20 | 48.5 | SF +7.5 | SF by 11 |
| 2022 WK 5 | SF 37atCAR 15 | 40 | CAR -6 | SF by 22 |
| 2019 WK 8 | CAR 13atSF 51 | 41 | SF +4.5 | SF by 38 |
| 2017 WK 1 | CAR 23atSF 3 | 45.5 | SF -4.5 | CAR by 20 |
| 2016 WK 2 | SF 27atCAR 46 | 44.5 | CAR +12 | CAR by 19 |
| 2013 DIV | SF 23atCAR 10 | 41 | CAR 0 | SF by 13 |
| 2013 WK 10 | CAR 10atSF 9 | 43 | SF +6 | CAR by 1 |
| 2010 WK 7 | SF 20atCAR 23 | 36.5 | CAR -1 | CAR by 3 |
| 2007 WK 13 | SF 14atCAR 31 | 35 | CAR +3 | CAR by 17 |
| 2004 WK 10 | CAR 37atSF 27 | 41.5 | SF +1.5 | CAR by 10 |
| 2001 WK 10 | SF 25atCAR 22 | 43 | CAR -7 | SF by 3 |
| 2001 WK 4 | CAR 14atSF 24 | 45 | SF +6.5 | SF by 10 |
| 2000 WK 8 | SF 16atCAR 34 | 50 | CAR +3 | CAR by 18 |
| 2000 WK 2 | CAR 38atSF 22 | 48 | SF -3 | CAR by 16 |
| 1999 WK 15 | SF 24atCAR 41 | 46 | CAR +7.5 | CAR by 17 |
| 1999 WK 6 | CAR 31atSF 29 | 44 | SF +5 | CAR by 2 |
CAR in the last meetings
- Last 30-3
- Last 52-3
- Last 106-4
The extremes
- Highest scoring2016 week 2 · SF 27 at CAR 4673 points
- Lowest scoring2013 week 10 · CAR 10 at SF 919 points
- Widest margin2019 week 8 · CAR 13 at SF 5138 points
By starting quarterback
regular season, 1999–2025| CAR | SF | Met | CAR record |
|---|---|---|---|
| Steve Beuerlein | Jeff Garcia | 4 | 4-0 |
| Chris Weinke | Jeff Garcia | 2 | 0-2 |
9 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
By head coach
regular season, 1999–2025| CAR | SF | Met | CAR record |
|---|---|---|---|
| George Seifert | Steve Mariucci | 6 | 4-2 |
| Ron Rivera | Kyle Shanahan | 2 | 1-1 |
7 further pairings met once each and are left out — a list where most rows read 1-0 describes single games rather than a matchup. Every one of them is in the table above.
Players, since 2021
a shorter window than aboveEverything above this line covers 1999 onwards, because that is how far the schedule and the closing lines go back. Per-player box scores start at 2021, so any figure naming a player covers the 5 seasons from 2021 and no more. The two windows are kept apart rather than blended, and neither is presented as the complete history: these clubs have played each other for far longer than this database reaches, and nothing on this page covers the seasons before 1999.
Most touchdowns
since 2021 · 2 meetings
- Jimmy Garoppolo QB · SF · 1g2 TD
- Tevin Coleman RB · SF · 1g2 TD
- Christian McCaffrey RB · CAR · 2g2 TD
- Jeff Wilson RB · SF · 1g1 TD
- Deebo Samuel Sr. WR · SF · 1g1 TD
- Jauan Jennings WR · SF · 1g1 TD
Most passing yards
since 2021 · 2 meetings
- Jimmy Garoppolo QB · SF · 1g253 yds
- Baker Mayfield QB · CAR · 1g215 yds
- Brock Purdy QB · SF · 1g193 yds
- Bryce Young QB · CAR · 1g169 yds
- PJ Walker QB · CAR · 1g60 yds
Most rushing yards
since 2021 · 2 meetings
- Christian McCaffrey RB · CAR · 2g143 yds
- Jeff Wilson RB · SF · 1g120 yds
- Brian Robinson RB · SF · 1g40 yds
- Rico Dowdle RB · CAR · 1g38 yds
- Tevin Coleman RB · SF · 1g23 yds
- Chuba Hubbard RB · CAR · 1g16 yds
Most receiving yards
since 2021 · 2 meetings
- George Kittle TE · SF · 2g125 yds
- Christian McCaffrey RB · CAR · 2g103 yds
- Jauan Jennings WR · SF · 2g86 yds
- Shi Smith WR · CAR · 1g69 yds
- DJ Moore WR · CAR · 1g59 yds
- Brandon Aiyuk WR · SF · 1g58 yds
